INT308987

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
macrophages 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 32 100.00 Very High Very High Very High
Inflammation 34 94.76 High High
cytokine 11 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
tramadol 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 4 98.04 Very High Very High Very High
Atherosclerosis 4 97.12 Very High Very High Very High
Disease 1 97.04 Very High Very High Very High
Obesity 126 95.52 Very High Very High Very High
INFLAMMATION 38 94.76 High High
Insulin Resistance 34 94.08 High High
Cardiovascular Disease 1 84.16 Quite High
Apoptosis 15 53.32 Quite High
Stress 2 30.32 Quite Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taking that into account, our results underline the important role of insulin receptor-dependent regulation of MMP-9 in macrophages and further extend it to another hyperinsulinemia-related disease state i.e. the development of obesity-associated inflammation and insulin resistance.
Regulation (role) of Regulation (regulation) of MMP-9 in macrophages associated with inflammation, obesity, metalloproteinase, hyperinsulinism, insulin resistance and disease
1) Confidence 0.17 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.95 Pain Relevance 0.44

General Comments

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