INT309137

Context Info Confidence 0.03 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.04

nucleus (Edc4, Creb1) nucleoplasm (Creb1) mitochondrion (Creb1) nucleolus (Creb1) DNA binding (Creb1) transcription factor binding (Creb1)

Edc4 (Rattus norvegicus) Creb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat bDMF 24 86.96 Hippocampus 14 40.80 ischemia 67 37.28 antagonist 8 5.00 anesthesia 4 5.00 agonist 2 5.00 cerebral cortex 1 5.00 Pyramidal cell 1 5.00 halothane 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 5 48.84 Cv General 4 Under Development 59 37.28 Targeted Disruption 9 11.72 Brain Hemorrhage 2 8.12 Cognitive Disorder 16 5.00 Death 6 5.00 Cv Unclassified Under Development 6 5.00 Stroke 6 5.00 Middle Cerebral Artery Infarction 3 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, our own findings revealed that EDC and E2-BSA enhanced phosphorylation of the transcription factor, CREB in a rapid fashion following reperfusion, and that this effect is ERK- and Akt-dependent.

EDC Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of CREB

1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0 Pain Relevance 0.04

General Comments

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