INT309142

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.12 Pain Relevance 0.13

cytoplasm (Edc4, Bcl2) nucleus (Edc4, Bcl2) mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)

Edc4 (Rattus norvegicus) Bcl2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat bDMF 24 95.88 ischemia 67 65.04 Hippocampus 14 55.68 antagonist 8 5.00 anesthesia 4 5.00 agonist 2 5.00 cerebral cortex 1 5.00 Pyramidal cell 1 5.00 halothane 1 5.00

Disease Link Frequency Relevance Heat Cv General 4 Under Development 59 65.04 Apoptosis 5 35.12 Cognitive Disorder 16 13.60 Targeted Disruption 9 5.00 Death 6 5.00 Cv Unclassified Under Development 6 5.00 Stroke 6 5.00 Middle Cerebral Artery Infarction 3 5.00 Brain Hemorrhage 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We also found that a second transcriptional target of CREB, Bcl-2, a potent antiapoptotic factor, was also induced by EDC in the hippocampal CA1 region following ischemic reperfusion (unpublished observation).

EDC Regulation (target) of Bcl-2

1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866326 Disease Relevance 0.12 Pain Relevance 0.13

General Comments

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