INT309713

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (GOPC, CALM3, CALM3) plasma membrane (GOPC, CALM3, CALM3) nucleoplasm (CALM3, CALM3)
small molecule metabolic process (CALM3, CALM3) carbohydrate metabolic process (CALM3, CALM3) cytosol (CALM3, CALM3)
Anatomy Link Frequency
lobe 4
GOPC (Homo sapiens)
CALM3 (Homo sapiens)
CALM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 57.96 Quite High
TRP channel 8 57.68 Quite High
addiction 4 42.12 Quite Low
adenocard 2 41.76 Quite Low
imagery 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaM mutants with a dysfunctional C lobe (CaM34, CaM1234) had no effect (Fig. 1F), probably because these mutants do not interact with the TRPV4 C-terminal domain and do not functionally compete with endogenous CaM.
Fig Neg (no) Regulation (effect) of CaM Neg (not) Binding (compete) of CaM34 in lobe
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.06
CaM mutants with a dysfunctional C lobe (CaM34, CaM1234) had no effect (Fig. 1F), probably because these mutants do not interact with the TRPV4 C-terminal domain and do not functionally compete with endogenous CaM.
Fig Neg (no) Regulation (effect) of CaM Neg (not) Binding (compete) of CaM in lobe
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.06

General Comments

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