INT309734

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytosol (CALM3, RPLP2) nucleoplasm (CALM3) structural constituent of ribosome (RPLP2) ribosome (RPLP2) small molecule metabolic process (CALM3) intracellular (RPLP2)

CALM3 (Homo sapiens) RPLP2 (Homo sapiens)

Pain Link Frequency Relevance Heat TRP channel 4 5.00 agonist 3 5.00 addiction 2 5.00 adenocard 1 5.00 imagery 1 5.00 qutenza 1 5.00

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

All data provide strong evidence for an interaction in TRPV4 between an N-terminal domain represented by the P2 peptide and a site in the C terminus, P5, that also binds to CaM.

CaM Binding (binds) of P2

1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.