INT309901

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SAT1) small molecule metabolic process (SAT1) intracellular (SAT1)
transferase activity, transferring acyl groups (SAT1) cellular nitrogen compound metabolic process (SAT1) cytoplasm (SAT1)
Anatomy Link Frequency
body 1
SAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 70 50.00 Quite Low
Inflammation 11 26.48 Quite Low
Cannabinoid receptor 14 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Cannabinoid 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 503 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 53 98.32 Very High Very High Very High
Overweight 4 76.96 Quite High
Insulin Resistance 10 69.12 Quite High
Disease 7 56.72 Quite High
Appetite Loss 2 54.28 Quite High
Diabetes Mellitus 70 50.00 Quite Low
Weight Loss 6 49.48 Quite Low
Stress 2 26.56 Quite Low
INFLAMMATION 13 26.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, since SAT LPL activity here correlated negatively with SAT AEA (and OEA or PEA) levels, while 2-AG levels showed an opposite tendency, it is possible to hypothesize, again, that increased AEA might not result in increased SAT CB1 activity, whereas decreased levels of 2-AG in the SAT might be partly responsible, via the corresponding reduction of CB1 activity, for the decreased LPL activity observed in this adipose depot.
Negative_regulation (decreased) of SAT associated with obesity
1) Confidence 0.13 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.43 Pain Relevance 0
With regard to 2-AG, here positively correlated with M-values, the reduced whole body insulin sensitivity cannot explain the reduction of its levels in the SAT of OBT2D subjects, since these subjects exhibited M-values similar to those of OB subjects.
Negative_regulation (reduction) of SAT in body associated with obesity
2) Confidence 0.11 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2868848 Disease Relevance 1.15 Pain Relevance 0
Of these, 26 are present in SAT modules 4 and 8, which are correlated to HDL levels.
Negative_regulation (present) of SAT associated with obesity and disorder of lipid metabolism
3) Confidence 0.05 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2925326 Disease Relevance 1.38 Pain Relevance 0

General Comments

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