INT31014

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Context Info
Confidence 0.27
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.11
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

methyltransferase activity (Setd1a) nucleus (Setd1a)
Anatomy Link Frequency
platelet 1
Setd1a (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 3 96.24 Very High Very High Very High
fluoxetine 1 95.36 Very High Very High Very High
Migraine 4 95.20 Very High Very High Very High
cINOD 3 94.96 High High
beta blocker 3 90.28 High High
Hippocampus 1 86.00 High High
Serotonin 1 77.60 Quite High
COX2 1 10.00 Low Low
cOX1 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Stress 5 98.60 Very High Very High Very High
Headache 4 95.20 Very High Very High Very High
Neurodegenerative Disease 1 83.20 Quite High
Affective Disorder 2 75.00 Quite High
Congenital Anomalies 1 73.32 Quite High
INFLAMMATION 1 71.04 Quite High
Manic Depressive Disorder 1 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cell cycle (not viability) is blocked concomitantly with NSC block.
Negative_regulation (block) of NSC
1) Confidence 0.27 Published 1993 Journal EXS Section Abstract Doc Link 7505659 Disease Relevance 0 Pain Relevance 0.09
The reduction in NSC number persisted for weeks after the cessation of stress, but was reversed by treatment with antidepressant drugs, fluoxetine and imipramine.
Negative_regulation (reduction) of NSC associated with stress, antidepressant and fluoxetine
2) Confidence 0.18 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108505 Disease Relevance 0.70 Pain Relevance 0.31
This effect was specific for COX-2 because maternal administration of a COX-1-selective inhibitor (SC58560) did not affect renal development despite significantly inhibiting gastric mucosal prostaglandin E2 (PGE2) synthesis in pups.
Negative_regulation (administration) of COX-1-selective
3) Confidence 0.04 Published 2000 Journal Kidney Int. Section Body Doc Link 10652018 Disease Relevance 0.14 Pain Relevance 0
We conclude that non-selective beta blockade increases factors, such as platelet aggregability, and decreases fibrinolytic activity compared with beta 1-selective blockade with metoprolol.
Negative_regulation (blockade) of beta 1-selective in platelet
4) Confidence 0.02 Published 1986 Journal Cephalalgia Section Abstract Doc Link 2879630 Disease Relevance 0.26 Pain Relevance 0.48

General Comments

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