INT310188

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

cytoplasm (Adcyap1r1, Smad7) plasma membrane (Adcyap1r1, Smad7) cell differentiation (Adcyap1r1) endosome (Adcyap1r1) intracellular (Smad7) protein complex (Smad7)

Adcyap1r1 (Mus musculus) Smad7 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 headache 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Cancer 55 36.44 Apoptosis 3 34.92 Hereditary Neoplastic Syndromes 2 20.32 Syndrome 14 6.72 Metastasis 12 5.00 Colon Cancer 7 5.00 Prostate Cancer 6 5.00 Disease 6 5.00 Leukemia 5 5.00 Melanoma 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

One of the feedback mechanisms is mediated by inhibitory SMADs (I-SMAD), in humans SMAD-6 and SMAD-7, which compete with the R-SMADs for binding to the type I receptor, but without the ability to transduce the downstream signal.

type I receptor Binding (binding) of SMAD-7

1) Confidence 0.00 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2871186 Disease Relevance 0 Pain Relevance 0

General Comments

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