INT310474

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.07 Pain Relevance 0.33

endoplasmic reticulum (Fate1) molecular_function (Fate1) biological_process (Fate1)

Anatomy Link Frequency neuronal 4 Fate1 (Mus musculus)

Pain Link Frequency Relevance Heat Neurotransmitter 6 97.40 GABAergic 80 92.72 cerebral cortex 56 80.64 imagery 20 5.00 interneuron 16 5.00 Action potential 14 5.00 antagonist 8 5.00 Glutamate 6 5.00 gABA 4 5.00 Potency 4 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 36 74.96 Brain Injury 4 42.72 Injury 22 25.00 Infection 74 5.00 Stab Wounds 10 5.00 Targeted Disruption 6 5.00 Stuttering 4 5.00 Vesicular Stomatitis 4 5.00 Epilepsy 2 5.00 Dislocations 2 5.00

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Towards this end, we first aimed at a more potent neuronal reprogramming by inducing higher and more persistent expression of neurogenic fate determinants in astroglial cells.

Positive_regulation (inducing) of Gene_expression (expression) of fate in neuronal

1) Confidence 0.04 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0 Pain Relevance 0.17

Importantly, the neurotransmitter fate choice of astroglia-derived neurons can be controlled by selective expression of distinct neurogenic transcription factors: forced expression of the dorsal telencephalic fate determinant neurogenin-2 (Neurog2) directs cortical astroglia to generate synapse-forming glutamatergic neurons; in contrast, the ventral telencephalic fate determinant Dlx2 induces a GABAergic identity, although the overall efficiency of Dlx2-mediated neuronal reprogramming is much lower compared to Neurog2, suggesting that cortical astroglia possess a higher competence to respond to the dorsal telencephalic fate determinant.

Positive_regulation (forced) of Gene_expression (expression) of fate in neuronal associated with neurotransmitter and gabaergic

2) Confidence 0.04 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2872647 Disease Relevance 0.07 Pain Relevance 0.16

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