INT310483

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.85 Pain Relevance 0.19

cell differentiation (Eomes) nucleus (Eomes) intracellular (Eomes) DNA binding (Eomes)

Eomes (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 40 93.96 gABA 2 83.16 antagonist 4 58.00 Glutamate receptor 1 57.56 Neurotransmitter 3 27.48 imagery 10 19.36 cytokine 8 17.00 cerebral cortex 29 5.00 cINOD 10 5.00 interneuron 8 5.00

Disease Link Frequency Relevance Heat Infection 54 97.20 Neurodegenerative Disease 29 94.48 Autism 6 76.60 Schizophrenia 8 71.12 Injury 11 5.00 INFLAMMATION 11 5.00 Congenital Anomalies 6 5.00 Influenza Virus Infection 5 5.00 Stab Wounds 5 5.00 Targeted Disruption 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Transition from RG to IPC is associated with upregulation of TBR2, a T-domain transcription factor, and downregulation of PAX6 (28–30).

Positive_regulation (upregulation) of TBR2

1) Confidence 0.38 Published 2010 Journal mBio Section Body Doc Link PMC2953007 Disease Relevance 0.43 Pain Relevance 0

Consistent with the specification of postnatal astroglia towards a glutamatergic identity, forced expression of Neurog2 resulted in the induction of the T-box transcription factors Tbr2 (Figure S1B and S1B') in 20.7%±1.9% of the DsRed-positive cells at 4 DPI (n?

Positive_regulation (induction) of Tbr2 associated with infection

2) Confidence 0.31 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2872647 Disease Relevance 0.42 Pain Relevance 0.19

General Comments

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