INT310678

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.76 Pain Relevance 0.04

ARSH (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 3 82.08 Spinal cord 8 5.00 cva 8 5.00 intrathecal 6 5.00 anesthesia 4 5.00 Antihistamine 2 5.00 ischemia 1 5.00 Inflammatory response 1 5.00 imagery 1 5.00 nud 1 5.00

Disease Link Frequency Relevance Heat Blindness 3 89.76 Optic Atrophy 3 89.20 Hydrocephalus 5 88.36 Pathologic Constriction 5 87.20 Multiple Sulfatase Deficiency Disease 14 79.20 Umbilical Hernia 2 78.68 Disease 52 77.32 Carpal Tunnel Syndrome 4 77.00 Apnoea 6 75.68 Hearing Impairment 5 75.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Over 130 ARSB mutations have been reported, causing absent or reduced arylsulfatase B (N-acetylgalactosamine 4-sulfatase) activity and interrupted dermatan sulfate and chondroitin sulfate degradation.

Neg (absent) Protein_catabolism (degradation) of sulfatase

1) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2873242 Disease Relevance 1.76 Pain Relevance 0.04

General Comments

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