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Context Info
Confidence 0.37
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.00
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HRH2) signal transducer activity (HRH2)
Anatomy Link Frequency
liver 1
parietal cell 1
eosinophils 1
HRH2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 19 100.00 Very High Very High Very High
cINOD 9 100.00 Very High Very High Very High
Versed 6 100.00 Very High Very High Very High
lidocaine 2 100.00 Very High Very High Very High
Clonidine 1 100.00 Very High Very High Very High
Antihistamine 4 99.98 Very High Very High Very High
agonist 1 96.80 Very High Very High Very High
tricyclic antidepressant 9 94.36 High High
depression 1 93.92 High High
peptic ulcer disease 3 82.04 Quite High
Disease Link Frequency Relevance Heat
Ulcers 9 99.28 Very High Very High Very High
Peptic Ulcer 2 98.68 Very High Very High Very High
Depression 1 93.92 High High
INFLAMMATION 8 93.64 High High
Arrhythmia Under Development 4 93.20 High High
Hookworm Infection 35 84.08 Quite High
Disease 5 82.04 Quite High
Congenital Anomalies 1 81.20 Quite High
Rhinitis 1 77.84 Quite High
Duodenal Ulcer 1 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacokinetic interactions between NSAIDs (indomethacin or sulindac) and H2-receptor antagonists (cimetidine or ranitidine) in human volunteers.
H2-receptor Binding (interactions) of associated with antagonist and cinod
1) Confidence 0.37 Published 1988 Journal Clin. Pharmacol. Ther. Section Title Doc Link 2901930 Disease Relevance 0.09 Pain Relevance 0.54
OBJECTIVE: To investigate potential interactions between lidocaine (lignocaine) metabolism and premedication drugs, i.e. psychotropic and antianxiety agents (diazepam, midazolam), hypnotics (pentobarbital, thiamylal), depolarizing neuromuscular blocking agents (vecuronium, pancuronium and suxamethonium), an antihypertensive agent (clonidine) and an H2-receptor blocking agent (cimetidine) using human liver microsomes in vitro.
H2-receptor Binding (interactions) of in liver associated with versed, lidocaine and clonidine
2) Confidence 0.37 Published 2005 Journal J Clin Pharm Ther Section Abstract Doc Link 15811173 Disease Relevance 0 Pain Relevance 0.33
In addition to their well-known anticholinergic properties, in vitro studies have indicated potent H1- and H2-receptor blocking activities for these agents.
H2-receptor Binding (activities) of
3) Confidence 0.37 Published 1984 Journal Arch. Intern. Med. Section Abstract Doc Link 6367680 Disease Relevance 0.58 Pain Relevance 0.61
Drug metabolism by rat and human hepatic microsomes in response to interaction with H2-receptor antagonists.
H2-receptor Binding (interaction) of associated with antagonist
4) Confidence 0.30 Published 1982 Journal Gastroenterology Section Title Doc Link 6118314 Disease Relevance 0 Pain Relevance 0.15
Pirenzepine and H2-receptor antagonists interact synergistically on parietal cell function; their combination seems to be of therapeutic advantage in defined indications.
H2-receptor Binding (interact) of in parietal cell associated with antagonist
5) Confidence 0.22 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 2881347 Disease Relevance 0.39 Pain Relevance 0.24
On the other hand, the release of histamine by activated eosinophils may downregulate DC differentiation through induction of IL-10 production by lymphocytes and mDCs, after interaction with histamine receptor type 2 (HR2) on these cells [53].
histamine receptor type 2 Binding (interaction) of in eosinophils
6) Confidence 0.04 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.66 Pain Relevance 0.09
Cimetidine inhibits antihistamine H2-receptor binding and is used in the treatment of gastric ulcers.
H2-receptor Binding (binding) of associated with antihistamine and peptic ulcer
7) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2584094 Disease Relevance 0.27 Pain Relevance 0.05

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