INT311025

Context Info Confidence 0.38 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.09

Anatomy Link Frequency dentin 2 Dspp (Mus musculus)

Pain Link Frequency Relevance Heat dexamethasone 2 93.20 Inflammation 6 5.00 cytokine 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Systemic Lupus Erythematosus 64 5.00 Death 10 5.00 Disease 10 5.00 Immune System Diseases 8 5.00 Autoimmune Disease 8 5.00 INFLAMMATION 6 5.00 Hypercalcemia 4 5.00 Graft Vs Host Disease 4 5.00 Osteoporosis 4 5.00 Obesity 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).

Positive_regulation (elevated) of dentin sialoprotein in dentin

1) Confidence 0.38 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.04

After one week of induction, SHED were similar to BMMSCs, showing significantly increased alkaline phosphatase (ALP) activity (Figure 2A) and the number of ALP-positive cells by flow cytometric analysis (Figure 2B), and expression of elevated levels of ALP, Runt related transcription factor 2 (Runx2), dentin sialoprotein (DSP), and osteocalcin (OCN) by immunoblot analysis (Figure 2C).

Positive_regulation (increased) of DSP in dentin

2) Confidence 0.28 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 0 Pain Relevance 0.05

General Comments

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