INT311395

Context Info Confidence 0.04 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.11 Pain Relevance 0

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1) cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)

Esr1 (Mus musculus) 20S (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2 5.00 Central nervous system 2 5.00 spastic colon 1 5.00 depression 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 19 54.72 Myotonic Dystrophy 22 50.00 Disease 13 50.00 Toxicity 16 5.00 Myotonia 14 5.00 Congenital Anomalies 11 5.00 Cataract 7 5.00 Frailty 7 5.00 Aging 5 5.00 Muscular Atrophy 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, the 20S proteasome complex in DM2 cells is associated with ER chaperone BiP, which is a master regulator of Unfolded Protein Response (UPR).

ER Binding (associated) of 20S

1) Confidence 0.04 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0.11 Pain Relevance 0

General Comments

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