INT311475

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.10
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Mllt1) nucleus (Mllt1) cytoplasm (Mllt1)
Mllt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Lamotrigine 226 100.00 Very High Very High Very High
antiepileptic Drug 44 98.42 Very High Very High Very High
carbamazepine 24 70.16 Quite High
Gabapentin 6 13.60 Low Low
anticonvulsant 6 5.00 Very Low Very Low Very Low
headache 6 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
cocaine 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Exanthema 36 97.76 Very High Very High Very High
Dizziness 8 90.00 High High
Diplopia 6 89.12 High High
Ataxia 6 88.32 High High
Vomiting 14 87.36 High High
Staphylococcus Infection 2 77.56 Quite High
Death 2 69.00 Quite High
Syndrome 18 64.20 Quite High
Cognitive Disorder 2 50.04 Quite High
Epilepsy 24 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adverse effects of both immediate and extended-release LTG formulations are listed in Table 2.
Regulation (effects) of Localization (release) of LTG associated with lamotrigine
1) Confidence 0.39 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874338 Disease Relevance 1.10 Pain Relevance 0.38
Generally, most of the newer AEDs have no impact on the activity of hepatic enzymes so they are not expected to affect pharmacokinetic parameters of LTG.16

Importance of extended-release formulations

Regulation (affect) of Localization (parameters) of LTG associated with lamotrigine and antiepileptic drug
2) Confidence 0.39 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874338 Disease Relevance 0 Pain Relevance 0.57

General Comments

This test has worked.

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