INT311557

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.32
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) cell differentiation (ROS1) cell proliferation (ROS1)
endoplasmic reticulum (Ptpn2) nucleus (Ptpn2) plasma membrane (ROS1)
Anatomy Link Frequency
neuronal 2
ROS1 (Homo sapiens)
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 10 84.96 Quite High
Substantia nigra 24 82.36 Quite High
ischemia 24 76.64 Quite High
monoamine 6 76.60 Quite High
Glutamate 34 73.12 Quite High
long-term potentiation 22 5.00 Very Low Very Low Very Low
Central nervous system 22 5.00 Very Low Very Low Very Low
Ventral tegmentum 18 5.00 Very Low Very Low Very Low
Hippocampus 16 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 20 100.00 Very High Very High Very High
Death 26 96.12 Very High Very High Very High
Stress 286 95.88 Very High Very High Very High
Disease 68 94.44 High High
Aging 32 80.48 Quite High
Neurodegenerative Disease 26 79.68 Quite High
Cv Unclassified Under Development 22 76.64 Quite High
Convulsion 2 75.84 Quite High
Toxicity 2 23.28 Low Low
Alzheimer's Dementia 2 15.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several agents that lead to the formation of ROS, including MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and paraquat, can reproduce a selective neuronal death pattern similar to that observed in PD (Moratalla et al., 1992; Brooks et al., 1999; McCormack et al., 2002).
ROS Binding (formation) of MPTP in neuronal associated with parkinson's disease, disease and death
1) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.16 Pain Relevance 0.23
Several agents that lead to the formation of ROS, including MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and paraquat, can reproduce a selective neuronal death pattern similar to that observed in PD (Moratalla et al., 1992; Brooks et al., 1999; McCormack et al., 2002).
ROS Binding (formation) of MPTP in neuronal associated with parkinson's disease, disease and death
2) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 1.16 Pain Relevance 0.23

General Comments

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