INT311656

Context Info Confidence 0.30 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.39 Pain Relevance 0

cytoplasm (Wnt1, Spry1) signal transduction (Wnt1) extracellular space (Wnt1) extracellular region (Wnt1) proteinaceous extracellular matrix (Wnt1) plasma membrane (Wnt1)

Anatomy Link Frequency embryos 2 Wnt1 (Mus musculus) Spry1 (Mus musculus)

Pain Link Frequency Relevance Heat midbrain 4 5.00 anesthesia 4 5.00 imagery 4 5.00 vagus nerve 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 54 100.00 Apoptosis 38 92.80 Sprains And Strains 2 18.52 Cleft Palate 16 5.00 Congenital Anomalies 14 5.00 Persistent Truncus Arteriosus 8 5.00 Ventricular Heart Septal Defects 8 5.00 Syndrome 2 5.00 Death 2 5.00 Polydactyly 2 5.00

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Anatomy

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Speculation

Pain term

Disease term

To gain insight into the possible mechanisms that contribute to the craniofacial defects observed in Spry1;Wnt1-Cre embryos we crossed the conditional CAGGFP-Spry1 mice with R26R;Wnt1-Cre transgenic mice to generate Spry1;R26R;Wnt1-Cre mutant embryos.

Wnt1 Binding (crossed) of CAGGFP-Spry1 in embryos associated with targeted disruption

1) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.19 Pain Relevance 0

To gain insight into the possible mechanisms that contribute to the craniofacial defects observed in Spry1;Wnt1-Cre embryos we crossed the conditional CAGGFP-Spry1 mice with R26R;Wnt1-Cre transgenic mice to generate Spry1;R26R;Wnt1-Cre mutant embryos.

Wnt1 Binding (crossed) of CAGGFP-Spry1 in embryos associated with targeted disruption

2) Confidence 0.30 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2874773 Disease Relevance 0.19 Pain Relevance 0

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