INT311668

From wiki-pain
Revision as of 07:06, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.58
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 2 81.48 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
Somatostatin 5 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Bile 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dna Damage 2 100.00 Very High Very High Very High
Paraganglioma 17 99.84 Very High Very High Very High
Apoptosis 10 99.16 Very High Very High Very High
Cancer 213 93.40 High High
Malignant Neoplastic Disease 19 92.44 High High
Breast Cancer 246 91.48 High High
Neuroendocrine Cancer 8 89.16 High High
Syndrome 4 86.72 High High
Advanced Or Metastatic Breast Cancer 8 81.00 Quite High
Metastasis 35 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we unfortunately have to conclude an immunohistochemical evaluation using bcl-2 or p53 in gangliocytic paraganglioma has a limited prognostic value mostly due to its rarity.
Regulation (evaluation) of Regulation (using) of p53 associated with paraganglioma
1) Confidence 0.36 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.18 Pain Relevance 0.04
It plays a central role in sensing genotoxic and non-genotoxic stresses and transducing an anti-proliferative effect80,82 (Fig. 1). p53 is activated and regulated by post-translational modifications to both the N- and C-terminal regions (e.g. phosphorylation, ubiquitination, and acetylation) and binds as a tetramer to specific DNA sequences via a central DNA-binding core region. p53 exerts its primary biologic function by modulating the transcription of dozens of genes.81,84 In mice, loss of p53 is associated with multiple spontaneous tumors77 and p53-loss accelerates the appearance of mammary tumors in murine mammary tissue that also overexpresses Myc, HER2/neu, IGF1, and/or Wnt1.85,86 Inheritance of a p53 mutant allele causes the rare familial Li-Fraumeni syndrome, characterized by multiple early-onset cancers, including breast cancer in women who survive childhood cancers.
Regulation (role) of Regulation (regulated) of p53 associated with dna damage, syndrome, cancer and breast cancer
2) Confidence 0.18 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.14 Pain Relevance 0
It plays a central role in sensing genotoxic and non-genotoxic stresses and transducing an anti-proliferative effect80,82 (Fig. 1). p53 is activated and regulated by post-translational modifications to both the N- and C-terminal regions (e.g. phosphorylation, ubiquitination, and acetylation) and binds as a tetramer to specific DNA sequences via a central DNA-binding core region. p53 exerts its primary biologic function by modulating the transcription of dozens of genes.81,84 In mice, loss of p53 is associated with multiple spontaneous tumors77 and p53-loss accelerates the appearance of mammary tumors in murine mammary tissue that also overexpresses Myc, HER2/neu, IGF1, and/or Wnt1.85,86 Inheritance of a p53 mutant allele causes the rare familial Li-Fraumeni syndrome, characterized by multiple early-onset cancers, including breast cancer in women who survive childhood cancers.
Regulation (modulating) of Regulation (regulated) of p53 associated with dna damage, syndrome, cancer and breast cancer
3) Confidence 0.18 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.26 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox