INT311966

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.46
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40) molecular_function (Cd40)
Anatomy Link Frequency
CD86 1
bowel 1
Cd40 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 2 100.00 Very High Very High Very High
Inflammation 15 98.00 Very High Very High Very High
Multiple sclerosis 1 92.48 High High
rheumatoid arthritis 38 83.88 Quite High
Infliximab 13 74.36 Quite High
cytokine 3 47.36 Quite Low
spastic colon 7 35.00 Quite Low
antagonist 7 34.96 Quite Low
abdominal pain 11 5.00 Very Low Very Low Very Low
Sicca syndrome 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 22 99.76 Very High Very High Very High
Mucositis 1 98.32 Very High Very High Very High
Inflammatory Bowel Disease 1 95.68 Very High Very High Very High
Autoimmune Disease 8 95.12 Very High Very High Very High
INFLAMMATION 16 93.08 High High
Demyelinating Disease 1 92.48 High High
Dermatomyositis 1 91.32 High High
Systemic Lupus Erythematosus 9 90.24 High High
Apoptosis 1 89.28 High High
Rheumatoid Arthritis 38 83.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased plasma levels of sCD40 and their correlation with the extent of mucosal inflammation have been recently reported in patients with inflammatory bowel disease [23].
Positive_regulation (Increased) of sCD40 in bowel associated with mucositis and inflammation
1) Confidence 0.50 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2885307 Disease Relevance 0.73 Pain Relevance 0.17
Immune-stimulatory activities relate to the activation of myeloid dendritic cells, chemokines, chemokine receptors, costimulatory molecules (CD40, CD80, and CD86), and humoral responses.
Positive_regulation (activation) of CD40 in CD86 associated with chemokine
2) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.74 Pain Relevance 0.32

General Comments

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