INT312595

Context Info Confidence 0.49 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0

signal transduction (Musk) plasma membrane (Musk) kinase activity (Musk)

Musk (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00 Action potential 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Congenital Myasthenic Syndromes 22 88.76 Syndrome 3 70.12 Disease 1 67.24 Muscle Weakness 2 57.76 Respiratory Failure 2 40.00 Myasthenia Gravis 3 5.00 Congenital Anomalies 2 5.00 Frailty 1 5.00 Ocular Toxicity (including Many Sub-types) 1 5.00 Cognitive Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to agrin, MuSK activation requires phosphorylation of its Tyr553 residue, located within the juxtamembrane consensus recognition site (NPXY), via the phosphotyrosine-binding domain (PTB domain)-containing protein Dok-7 (11).

Positive_regulation (requires) of Positive_regulation (activation) of MuSK

1) Confidence 0.49 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.51 Pain Relevance 0

General Comments

This test has worked.