INT312634

Context Info Confidence 0.68 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.37 Pain Relevance 0

plasma membrane (Dok7, Musk) lipid binding (Dok7) signal transduction (Musk) kinase activity (Musk)

Anatomy Link Frequency Tid1 1 Dok7 (Mus musculus) Musk (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 5.00 Action potential 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Congenital Myasthenic Syndromes 22 75.84 Respiratory Failure 2 69.68 Syndrome 3 57.20 Disease 1 54.32 Muscle Weakness 2 44.84 Myasthenia Gravis 3 5.00 Congenital Anomalies 2 5.00 Frailty 1 5.00 Ocular Toxicity (including Many Sub-types) 1 5.00 Cognitive Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The dual activation of MuSK extracellularly by agrin and intracellularly by Dok-7 and Tid1 results in the recruitment of several downstream kinases and phosphorylation of the AChR ?

Dok-7 Positive_regulation (activation) of MuSK in Tid1

1) Confidence 0.68 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.37 Pain Relevance 0

General Comments

This test has worked.