INT312636

Context Info Confidence 0.21 First Reported 2010 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0.06

plasma membrane (Musk, Lrp4) anatomical structure development (Lrp4) signal transduction (Musk) kinase activity (Musk)

Musk (Mus musculus) Lrp4 (Mus musculus)

Pain Link Frequency Relevance Heat anesthesia 1 63.52 Action potential 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 2 83.08 Congenital Myasthenic Syndromes 22 81.92 Myasthenia Gravis 3 5.00 Syndrome 3 5.00 Respiratory Failure 2 5.00 Muscle Weakness 2 5.00 Frailty 1 5.00 Ocular Toxicity (including Many Sub-types) 1 5.00 Cognitive Disorder 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, the abnormal function of the MuSK mutants can not be explained on the basis of an impaired interaction between agrin and MuSK through the co-receptor Lrp4.

Negative_regulation (impaired) of MuSK Neg (impaired) Binding (interaction) of Lrp4

1) Confidence 0.21 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.32 Pain Relevance 0.06

General Comments

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