INT312731

Context Info Confidence 0.36 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.38 Pain Relevance 0.94

endoplasmic reticulum (UGT2B15)

UGT2B15 (Homo sapiens)

Pain Link Frequency Relevance Heat diclofenac 2 99.70 cINOD 8 99.60 Pain 2 86.88 Bioavailability 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 2 99.08 Pain 2 86.88 Renal Disease 36 61.12 Proteinuria 4 42.88 Focal Segmental Glomerulosclerosis 10 40.80 Injury 16 35.28 Keloid Scars 4 33.20 Urinary Tract Infection 2 13.20 Chronic Renal Failure 8 10.16 Obesity 22 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, use of steroids together with NSAIDs will competitively inhibit the steroid glucuronidation activity of UGT2B15.

Negative_regulation (inhibit) of UGT2B15 associated with cinod

1) Confidence 0.36 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.23 Pain Relevance 0.48

Sten et al. discovered that commonly used over-the-counter (OTC) non steroidal anti-inflammatory drugs (NSAIDs) like diclofenac and ibuprofen inhibited the testosterone glucuronidation activity of UGT2B17, UGT2B15 and some other UGTs that have previously shown low but detectable activity [43].

Negative_regulation (inhibited) of UGT2B15 associated with inflammation, cinod and diclofenac

2) Confidence 0.36 Published 2010 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2877023 Disease Relevance 0.15 Pain Relevance 0.46

General Comments

This test has worked.