INT312778

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.37
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 4
Pon1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 30 97.32 Very High Very High Very High
chemokine 2 54.32 Quite High
Inflammatory response 2 40.16 Quite Low
cytokine 2 33.08 Quite Low
fibrosis 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Disease 28 99.24 Very High Very High Very High
INFLAMMATION 32 97.32 Very High Very High Very High
Stress 20 97.04 Very High Very High Very High
Hyperlipidemia 2 95.60 Very High Very High Very High
Targeted Disruption 6 88.32 High High
Atherosclerosis 2 80.56 Quite High
Hepatotoxicity 4 80.08 Quite High
Disorder Of Lipid Metabolism 148 62.16 Quite High
Necrosis 2 44.96 Quite Low
Cancer 2 44.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In previous studies, we reported that serum PON1 activity is decreased in patients with chronic liver impairment, while serum PON1 concentration and hepatic PON1 protein expression are increased [21-23].
Positive_regulation (increased) of Gene_expression (expression) of PON1 protein in liver
1) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.17 Pain Relevance 0.12
The liver plays a key role in the synthesis of PON1 [18], and chronic liver diseases are associated with increased oxidative stress, MCP-1 synthesis, and inflammation [19,20].
Positive_regulation (role) of Gene_expression (synthesis) of PON1 in liver associated with stress, liver disease and inflammation
2) Confidence 0.39 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.20 Pain Relevance 0.19

General Comments

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