INT312830

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.45
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins2) extracellular region (Ins2) nucleus (Ins2)
carbohydrate metabolic process (Ins2) cytoplasm (Ins2)
Anatomy Link Frequency
developmental stage 1
Ins2 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 21 89.64 High High
diabetic neuropathy 53 86.72 High High
sodium channel 5 82.00 Quite High
Neuropathic pain 3 73.20 Quite High
nav1.3 1 59.92 Quite High
Nav1.6 1 59.28 Quite High
nav1.8 1 58.64 Quite High
analgesia 1 58.56 Quite High
Nav1.9 1 57.76 Quite High
tolerance 26 46.56 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 22 94.72 High High
Diabetes Mellitus 83 92.20 High High
Peripheral Neuropathy 53 86.72 High High
Hyperglycemia 20 85.84 High High
Injury 2 75.88 Quite High
Hypesthesia 1 75.56 Quite High
Neuropathic Pain 7 73.20 Quite High
Aging 10 70.72 Quite High
Diabetic Neuropathy 1 50.00 Quite Low
Disease 3 48.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, both myelin and cholesterol metabolism gene expression was not affected in Ins2Akita/+ mice, thereby confirming previously observed stability of myelin structure even at a later developmental stage (48 weeks) in this model [36].
Neg (not) Regulation (affected) of Ins2Akita in developmental stage
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877074 Disease Relevance 0.86 Pain Relevance 0.66
Cross-sectional data do not automatically allow inferences about changes in insulin and proinsulin over time or with age, as differences by cross-sectional age groups could reflect secular as well as age trends.
Regulation (changes) of proinsulin
2) Confidence 0.19 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC3020169 Disease Relevance 0.13 Pain Relevance 0
In the same persons we considered the influence of age on insulin, proinsulin, and the proinsulin/insulin ratio, after adjustment for the concomitant glucose concentrations, several covariates associated with insulin resistance, and the time since the last meal.
Regulation (influence) of proinsulin associated with insulin resistance
3) Confidence 0.08 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC3020169 Disease Relevance 0.46 Pain Relevance 0

General Comments

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