INT312933

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Context Info
Confidence 0.63
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 7.94
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hes3) DNA binding (Hes3) transcription factor binding (Hes3)
Anatomy Link Frequency
nucleus 6
stem cells 4
precursor cell 1
Hes3 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 95 100.00 Very High Very High Very High
Perioperative pain 38 57.04 Quite High
cytokine 19 53.52 Quite High
Central nervous system 19 42.88 Quite Low
imagery 38 5.00 Very Low Very Low Very Low
anesthesia 19 5.00 Very Low Very Low Very Low
isoflurane 19 5.00 Very Low Very Low Very Low
Hippocampus 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioblastoma 19 99.96 Very High Very High Very High
Vibrio Infection 437 99.28 Very High Very High Very High
Brain Tumor 19 98.68 Very High Very High Very High
Malignant Neoplastic Disease 19 98.16 Very High Very High Very High
Cancer 57 98.08 Very High Very High Very High
Neurological Disease 57 91.68 High High
Stress 38 86.16 High High
Disease 57 85.20 High High
Stroke 57 78.96 Quite High
Bordatella Infection 19 70.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A key finding is that the localization of Hes3 correlates strongly with the proliferative state of stem cells: Quiescent endogenous stem cells throughout the adult brain exclude Hes3 from the nucleus but express it in the cytoplasm; when placed in culture under mitogenic support that promotes proliferation, Hes3 is found in both the cytoplasm and nucleus.
Localization (found) of Hes3 in stem cells
1) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.69 Pain Relevance 0
Similarly, in human biopsies from Grade IV Glioblastoma multiforme, Hes3 is found in both the cytoplasm and nucleus.
Localization (found) of Hes3 in nucleus associated with glioblastoma
2) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.70 Pain Relevance 0
When fetal NSCs were treated with CholAB for 2 days (following 4 days in FGF2), the nuclear localization of Hes3 markedly increased.
Localization (localization) of Hes3
3) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.06 Pain Relevance 0.08
A key finding is that the localization of Hes3 correlates strongly with the proliferative state of stem cells: Quiescent endogenous stem cells throughout the adult brain exclude Hes3 from the nucleus but express it in the cytoplasm; when placed in culture under mitogenic support that promotes proliferation, Hes3 is found in both the cytoplasm and nucleus.
Localization (localization) of Hes3 in stem cells
4) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.69 Pain Relevance 0
In culture conditions that support the self-renewal of mouse fetal NSCs in vitro (in the presence of FGF2), Hes3 is localized both in the nucleus and the cytoplasm of fetal NSCs (Figure 3a,b; Figure S2; Figure S3), whereas when differentiation is induced (by a 2-day FGF2 withdrawal), Hes3 is only found in the cytoplasm.
Localization (localized) of Hes3 in nucleus associated with withdrawal
5) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.13 Pain Relevance 0.05
Here we show that a cell biology mechanism that is activated by cholera toxin converges into this pathway (at the levels of receptor trafficking and Hes3 localization) to regulate stem cell and precursor cell numbers.
Localization (localization) of Hes3 in stem cell associated with vibrio infection
6) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.39 Pain Relevance 0
Cholera toxin increases immunoreactivity for the Tie2 receptor and rapidly induces the nuclear localization of Hes3.
Localization (localization) of Hes3 associated with vibrio infection
7) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877108 Disease Relevance 0.35 Pain Relevance 0
A key finding is that the localization of Hes3 correlates strongly with the proliferative state of stem cells: Quiescent endogenous stem cells throughout the adult brain exclude Hes3 from the nucleus but express it in the cytoplasm; when placed in culture under mitogenic support that promotes proliferation, Hes3 is found in both the cytoplasm and nucleus.
Localization (found) of Hes3 in stem cells
8) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.69 Pain Relevance 0
In culture conditions that support the self-renewal of mouse fetal NSCs in vitro (in the presence of FGF2), Hes3 is localized both in the nucleus and the cytoplasm of fetal NSCs (Figure 3a,b; Figure S2; Figure S3), whereas when differentiation is induced (by a 2-day FGF2 withdrawal), Hes3 is only found in the cytoplasm.
Localization (found) of Hes3 in nucleus associated with withdrawal
9) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.13 Pain Relevance 0.08
This is supported by our mechanistic data showing that treatment with the full (active) cholera toxin protein increases immunostaining for the Tie2 receptor and induces the nuclear localization of the transcription factor Hes3, two processes characteristic of self renewing NSCs [22], [23], [24], [25].
Localization (localization) of Hes3 associated with vibrio infection
10) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.49 Pain Relevance 0
Uncovering novel treatments that will affect Hes3 expression and localization will be a new set of tools in regenerative and cancer medicine.


Localization (localization) of Hes3 associated with cancer
11) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.76 Pain Relevance 0.06
Cholera toxin increases immunoreactivity for the Tie2 receptor and rapidly induces the nuclear localization of Hes3.
Localization (localization) of Hes3 associated with vibrio infection
12) Confidence 0.55 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2877108 Disease Relevance 0.35 Pain Relevance 0
Similarly, in human biopsies from Grade IV Glioblastoma multiforme, Hes3 is found in both the cytoplasm and nucleus.
Localization (found) of Hes3 in nucleus associated with glioblastoma
13) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.70 Pain Relevance 0
This is supported by our mechanistic data showing that treatment with the full (active) cholera toxin protein increases immunostaining for the Tie2 receptor and induces the nuclear localization of the transcription factor Hes3, two processes characteristic of self renewing NSCs [22], [23], [24], [25].
Localization (localization) of Hes3 associated with vibrio infection
14) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.49 Pain Relevance 0
In culture conditions that support the self-renewal of mouse fetal NSCs in vitro (in the presence of FGF2), Hes3 is localized both in the nucleus and the cytoplasm of fetal NSCs (Figure 3a,b; Figure S2; Figure S3), whereas when differentiation is induced (by a 2-day FGF2 withdrawal), Hes3 is only found in the cytoplasm.
Localization (found) of Hes3 in nucleus associated with withdrawal
15) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.07 Pain Relevance 0.08
In culture conditions that support the self-renewal of mouse fetal NSCs in vitro (in the presence of FGF2), Hes3 is localized both in the nucleus and the cytoplasm of fetal NSCs (Figure 3a,b; Figure S2; Figure S3), whereas when differentiation is induced (by a 2-day FGF2 withdrawal), Hes3 is only found in the cytoplasm.
Localization (localized) of Hes3 in nucleus associated with withdrawal
16) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.13 Pain Relevance 0.08
When fetal NSCs were treated with CholAB for 2 days (following 4 days in FGF2), the nuclear localization of Hes3 markedly increased.
Localization (localization) of Hes3
17) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.06 Pain Relevance 0.08
Our findings show that cholera toxin regulates the expression and localization of Tie2 and Hes3 and induces powerful expansion of cultured NSCs.


Localization (localization) of Hes3 associated with vibrio infection
18) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.66 Pain Relevance 0.03
Here we show that a cell biology mechanism that is activated by cholera toxin converges into this pathway (at the levels of receptor trafficking and Hes3 localization) to regulate stem cell and precursor cell numbers.
Localization (localization) of Hes3 in precursor cell associated with vibrio infection
19) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.39 Pain Relevance 0

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