INT312935

Context Info Confidence 0.35 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.59 Pain Relevance 0.11

nucleus (Hes3) DNA binding (Hes3) transcription factor binding (Hes3)

Hes3 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 2 91.12 cytokine 2 68.80 Hippocampus 2 64.44 withdrawal 10 24.96 Perioperative pain 4 5.00 imagery 4 5.00 anesthesia 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Disease 6 87.96 Stroke 6 87.00 Vibrio Infection 46 84.72 Injury 2 70.84 Cancer 6 56.24 Stress 4 12.56 Neurological Disease 6 5.00 Camurati-engelmann Disease 4 5.00 Post Operative Pain 4 5.00 Glioblastoma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These factors were selected because they converge onto a signal transduction pathway that is critical for the survival of NSCs and involves phosphorylation of STAT3 on the serine residue and induction of the transcription factor Hes3.

Regulation (involves) of Hes3

1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.36 Pain Relevance 0.11

Tie2 and Hes3 immunoreactivity are lost following induction of differentiation.

Regulation (immunoreactivity) of Hes3

2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.23 Pain Relevance 0

General Comments

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