INT312939

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.66 Pain Relevance 0

nucleus (Hes3, Setd1a) methyltransferase activity (Setd1a) DNA binding (Hes3) transcription factor binding (Hes3)

Anatomy Link Frequency brain 1 Hes3 (Mus musculus) Setd1a (Mus musculus)

Pain Link Frequency Relevance Heat Perioperative pain 2 7.44 withdrawal 5 5.00 imagery 2 5.00 cytokine 1 5.00 Central nervous system 1 5.00 anesthesia 1 5.00 isoflurane 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Malignant Neoplastic Disease 1 98.44 Brain Tumor 1 98.04 Neurological Disease 3 97.72 Disease 3 91.24 Vibrio Infection 23 81.08 Glioblastoma 1 62.48 Cancer 3 46.56 Bordatella Infection 1 33.80 Stroke 3 29.36 Post Operative Pain 2 7.44

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Recently, we have also shown that the presence of Hes3 marks not only the normal endogenous NSC but also the stem cell compartment in malignant brain tumors [24].

Hes3 Binding (presence) of NSC in brain associated with malignant neoplastic disease and brain tumor

1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0.66 Pain Relevance 0

General Comments

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