INT313014

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Htt (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 18 50.00 Quite Low
Inflammation 22 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 56 99.80 Very High Very High Very High
Targeted Disruption 15 92.04 High High
Stress 1 83.16 Quite High
Lung Cancer 7 71.92 Quite High
Nicotine Addiction 15 66.60 Quite High
Apoptosis 16 58.64 Quite High
INFLAMMATION 40 50.00 Quite Low
Communicable Diseases 1 39.52 Quite Low
Infection 7 37.04 Quite Low
Congenital Anomalies 3 35.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First of all, BC metabolism in humans is highly variable [16, 17] and most of this variability can be attributed to differences in enzymatic activity of the beta-carotene 15,15?
Positive_regulation (attributed) of 15,15 Binding (activity) of
1) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0.57 Pain Relevance 0
PSA suppresses accumulation of mutant huntingtin aggregates and toxicity in vivo
Positive_regulation (accumulation) of huntingtin Binding (aggregates) of associated with toxicity
2) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.16 Pain Relevance 0
Thus, a decrease of only 50% in the endogenous PSA activity is sufficient to significantly enhance mutant huntingtin aggregate formation, as was also found upon treatment of 293A cells with PSA inhibitors.
Positive_regulation (sufficient) of huntingtin Binding (formation) of
3) Confidence 0.07 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2972693 Disease Relevance 0.18 Pain Relevance 0

General Comments

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