INT313301

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.58
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SQSTM1, KEAP1) nucleus (SQSTM1, KEAP1) cell differentiation (SQSTM1)
nucleoplasm (SQSTM1) endoplasmic reticulum (KEAP1) response to stress (SQSTM1)
SQSTM1 (Homo sapiens)
KEAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 4 66.20 Quite High
Pain 4 65.56 Quite High
Glutamate 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 12 93.72 High High
Stress 28 88.08 High High
Spontaneous Fractures 4 67.28 Quite High
Osteoarthritis 4 66.20 Quite High
Pain 4 65.56 Quite High
Adenocarcinoma 8 15.20 Low Low
Hepatocellular Cancer 8 13.28 Low Low
Neuroblastoma 4 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In demonstrating that SQSTM1 regulates the degradation of Keap1, this work has uncovered an additional layer of regulatory control within the Keap1-Nrf2 cytoprotective pathway.


SQSTM1 Regulation (regulates) of Protein_catabolism (degradation) of Keap1
1) Confidence 0.43 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.41 Pain Relevance 0.10
In doing so, we have provided evidence that SQSTM1 can control the integrity of the Keap1-Nrf2 pathway, by regulating the degradation of Keap1 and, consequently, the basal activity of Nrf2.
SQSTM1 Regulation (regulating) of Protein_catabolism (degradation) of Keap1
2) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.08 Pain Relevance 0
Furthermore, evidence is provided to support the concept that SQSTM1 serves an important function in regulating the degradation of Keap1 and thus the integrity of the Keap1-Nrf2 pathway.
SQSTM1 Regulation (regulating) of Protein_catabolism (degradation) of Keap1
3) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.09 Pain Relevance 0
These results indicate that SQSTM1 can influence the basal level of Keap1 by regulating its degradation and therefore contribute to the integrity of the Keap1-Nrf2 pathway.
SQSTM1 Regulation (regulating) of Protein_catabolism (degradation) of Keap1
4) Confidence 0.23 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0

General Comments

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