INT313310

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Context Info
Confidence 0.43
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (KEAP1, SQSTM1) nucleus (KEAP1, SQSTM1) cell differentiation (SQSTM1)
nucleoplasm (SQSTM1) endoplasmic reticulum (KEAP1) response to stress (SQSTM1)
KEAP1 (Homo sapiens)
SQSTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 2 92.56 High High
Hepatocellular Cancer 2 89.20 High High
Stress 7 5.00 Very Low Very Low Very Low
Bone Disease 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuroblastoma 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Spontaneous Fractures 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the biological significance of the interaction between Keap1 and SQSTM1, we examined the effect on Keap1 of depleting endogenous SQSTM1, using siRNA, or ectopically expressing SQSTM1-FLAG/His in a panel of human cell lines originating from discrete organs.
Keap1 Spec (examined) Regulation (effect) of Gene_expression (expressing) of SQSTM1
1) Confidence 0.43 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.35 Pain Relevance 0

General Comments

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