INT313320

Context Info Confidence 0.68 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.14

cell differentiation (SQSTM1) cytosol (SQSTM1) nucleoplasm (SQSTM1) nucleus (SQSTM1) response to stress (SQSTM1) cytoplasm (SQSTM1)

SQSTM1 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 1 95.96 Pain 1 95.32 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Spontaneous Fractures 1 97.04 Osteoarthritis 1 95.96 Pain 1 95.32 Bone Disease 3 90.40 Stress 7 62.76 Adenocarcinoma 2 5.00 Hepatocellular Cancer 2 5.00 Neuroblastoma 1 5.00 Repression 1 5.00 Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The overwhelming majority of these mutations result in an impaired ability of SQSTM1 to bind ubiquitin (29).

Localization (ability) of SQSTM1

1) Confidence 0.68 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.59 Pain Relevance 0.14

General Comments

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