INT313627

Context Info Confidence 0.26 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0.85

transport (Grin2d) plasma membrane (Grin2d)

Anatomy Link Frequency lamina 1 Grin2d (Mus musculus)

Pain Link Frequency Relevance Heat nMDA receptor 79 99.96 GABAergic 14 97.52 Glutamate 7 90.56 Dorsal horn 13 82.68 Neuropathic pain 1 79.60 Inflammation 2 70.36 Pain 5 66.72 isoflurane 1 38.88 gABA 1 14.40 nMDA receptor antagonist 2 12.84

Disease Link Frequency Relevance Heat Nervous System Injury 3 84.68 Apoptosis 1 81.68 Neuropathic Pain 5 79.60 Death 2 77.12 INFLAMMATION 2 70.36 Injury 1 69.72 Pain 5 66.72 Targeted Disruption 3 5.00 Disseminated Intravascular Coagulation 3 5.00 Drug Induced Neurotoxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, we demonstrated that NR2A and NR2B containing receptors with high Mg2+ sensitivity and NR2D containing NMDA receptors with low Mg2+ sensitive are both expressed on GABAergic lamina II interneurons.

NR2D Binding (containing) of in lamina associated with gabaergic and nmda receptor

1) Confidence 0.26 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.60 Pain Relevance 0.85

General Comments

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