INT31383

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Context Info
Confidence 0.41
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.49
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nerve 1
finger 1
Gbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
noradrenaline 5 98.70 Very High Very High Very High
Somatostatin 4 96.92 Very High Very High Very High
antagonist 6 91.08 High High
Clonidine 3 87.56 High High
Inflammation 2 75.56 Quite High
cytokine 2 75.04 Quite High
Serotonin 11 37.84 Quite Low
agonist 6 37.12 Quite Low
corticosteroid 1 28.48 Quite Low
dexamethasone 1 26.56 Quite Low
Disease Link Frequency Relevance Heat
Aging 57 98.14 Very High Very High Very High
Bordatella Infection 6 83.72 Quite High
Sprains And Strains 47 82.28 Quite High
Shock 4 79.12 Quite High
INFLAMMATION 2 75.56 Quite High
Apoptosis 8 73.76 Quite High
Adhesions 1 72.68 Quite High
Targeted Disruption 9 62.00 Quite High
Cancer 24 58.40 Quite High
Hallucination 2 48.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several genes related to senescence were found to be significantly upregulated in senescent cells vs. non-senescent cells: p38 (MPAK14), RB-Associated KRAB zinc finger, Discoidin, CUB and LCCL domain, growth arrest and DNA-damage inducible beta, inhibitor of growth family member 5 (p28ING5), sphingosine-1-phosphate receptor 2 and somatostatin receptor 3.
Negative_regulation (inhibitor) of MPA in finger associated with aging and somatostatin
1) Confidence 0.41 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.67 Pain Relevance 0.12
These results suggest that alpha 2-adrenoceptor modulation of noradrenaline release from sympathetic nerve terminals is not dependent on an inhibitory guanine-nucleotide-binding protein.
Negative_regulation (inhibitory) of guanine-nucleotide-binding protein in nerve associated with noradrenaline
2) Confidence 0.28 Published 1987 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2891042 Disease Relevance 0.42 Pain Relevance 0.28
were significantly downregulated in both BALB/c MPA-treated and progesterone-treated mice, and it is interesting to note that ER-?
Negative_regulation (downregulated) of MPA-treated
3) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.40 Pain Relevance 0
Consistent with SEA prediction, one such phenotypic hit, MAG-1, was found to be a 1 nM inhibitor of MAO in direct kinetic inhibition studies (58).
Negative_regulation (inhibitor) of MAG-1
4) Confidence 0.02 Published 2010 Journal Biochemistry Section Body Doc Link PMC2994275 Disease Relevance 0 Pain Relevance 0

General Comments

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