INT313871

Context Info Confidence 0.49 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.97 Pain Relevance 0

cytosol (Pde5a) signal transduction (Pde5a) oxidoreductase activity (Pah)

Anatomy Link Frequency lung 1 Pde5a (Mus musculus) Pah (Mus musculus)

Pain Link Frequency Relevance Heat headache 3 5.00 cva 2 5.00 Calcium channel 2 5.00 carbamazepine 1 5.00 fibrosis 1 5.00 adenocard 1 5.00 Bioavailability 1 5.00 beta blocker 1 5.00 Inflammatory mediators 1 5.00 Potency 1 5.00

Disease Link Frequency Relevance Heat Pulmonary Hypertension 66 100.00 Increased Venous Pressure Under Development 5 90.12 Hypoxia 4 82.44 Reprotox - General 2 5 43.88 Cv General 4 Under Development 22 37.88 Hyperplasia 1 17.12 Apoptosis 2 16.04 Disease 17 5.44 Hypertension 6 5.00 Nonarteritic Anterior Ischaemic Optic Neuropathy 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PDE-5 has been the focus for PAH because the PDE-5 enzyme is highly expressed in lung tissue compared to other vascular beds, with minimal expression in the systemic circulation.15,16 PDE-5 expression is upregulated in PAH, leading to increased metabolism of NO-derived cGMP.

PDE-5 Positive_regulation (upregulated) of PAH in lung associated with pulmonary hypertension

1) Confidence 0.49 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2880338 Disease Relevance 0.97 Pain Relevance 0

General Comments

This test has worked.