INT313929

Context Info Confidence 0.39 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.54 Pain Relevance 0.17

cell proliferation (Thpo) extracellular space (Thpo) extracellular region (Thpo)

Anatomy Link Frequency platelets 2 Thpo (Mus musculus)

Pain Link Frequency Relevance Heat agonist 8 100.00 headache 2 18.44 anesthesia 1 10.00 cva 3 5.00 corticosteroid 1 5.00 fibrosis 1 5.00 dexamethasone 1 5.00 peptic ulcer disease 1 5.00

Disease Link Frequency Relevance Heat Leukemia 1 97.96 Myelodysplastic Syndromes 4 96.60 Hematologic Neoplasms 1 93.60 Emergencies 1 76.68 Thrombocytopenia 60 64.24 Adverse Drug Reaction 2 59.04 Hemorrhage 15 54.20 Purpura 4 50.00 Disease 5 34.00 Headache 2 18.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

After cessation of TPO agonist this effect was reversible in all but 1 patient, who progressed to secondary acute myeloid leukemia.42 Increasing platelet survival: splenectomy, immunoglobulins and vinca loaded platelets

Negative_regulation (reversible) of Negative_regulation (cessation) of TPO in platelets associated with leukemia and agonist

1) Confidence 0.39 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880346 Disease Relevance 0.54 Pain Relevance 0.17

General Comments

This test has worked.