INT31396

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Context Info
Confidence 0.41
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.26
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Lor) protein binding, bridging (Lor)
Anatomy Link Frequency
plasma 1
Lor (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 3 97.32 Very High Very High Very High
Opioid 3 97.08 Very High Very High Very High
agonist 4 95.12 Very High Very High Very High
Dopamine 1 84.88 Quite High
Clonidine 1 61.36 Quite High
Ultiva 2 50.00 Quite Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1 97.90 Very High Very High Very High
Muscle Rigidity 2 90.08 High High
Body Weight 6 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Unconsciousness 4 5.00 Very Low Very Low Very Low
Acid Reflux 2 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid antagonists reversed the entire syndrome--LOR and rigidity but, generally, rigidity could be reversed nonspecifically by doses of compounds that caused LOR by themselves (e.g., CNS depressants).
Positive_regulation (caused) of LOR associated with syndrome, antagonist and opioid
1) Confidence 0.41 Published 1987 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2891145 Disease Relevance 0.26 Pain Relevance 0.52
At LOR(verbal), BIS(50), SE(50) and RE(50) increased with increasing Ce(REMI).
Positive_regulation (increased) of LOR
2) Confidence 0.40 Published 2004 Journal Br J Anaesth Section Body Doc Link 15321934 Disease Relevance 0 Pain Relevance 0
We investigated the method for calculation of ke0 derived from t1/2ke0, which is ln2/ke0, at which the effect-site concentration becomes half of the target plasma concentration with a certain probability of LOR.
Positive_regulation (probability) of LOR in plasma
3) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0
We compared mean effect site concentrations for LOR, and also found effect site concentrations of propofol that could represent LOR in 50% (Ce50) and 95% (Ce95) of subjects for each ke0s.
Positive_regulation (represent) of LOR
4) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872834 Disease Relevance 0 Pain Relevance 0

General Comments

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