INT314063

Context Info Confidence 0.22 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.64 Pain Relevance 0.32

mitochondrion (Peo1) helicase activity (Peo1)

Anatomy Link Frequency macrophage 1 Peo1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 56 88.24 agonist 2 86.40 cytokine 22 78.60 Inflammatory mediators 2 51.36 Crohn's disease 8 5.00 chemokine 6 5.00 Piles 4 5.00 aspirin 2 5.00 cINOD 2 5.00 Bioavailability 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 54 88.24 Colitis 38 80.64 Inflammatory Bowel Disease 76 77.92 Disease 30 77.40 Hyperplasia 2 43.40 Body Weight 10 5.00 Cancer 10 5.00 Hemorrhage 10 5.00 Toxicity 4 5.00 Diarrhoea 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Subsequently, we performed a gene array analysis (Table 5) using the same in vitro macrophage based system to elucidate additional immune signaling genes that could be potential targets of PEO activity.

Regulation (targets) of PEO in macrophage

1) Confidence 0.22 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.34 Pain Relevance 0.28

Therefore, we wanted to study the effects of PEO on activated (phosphorylated at Tyr701) STAT1 (pSTAT1).

Regulation (effects) of PEO

2) Confidence 0.19 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.30 Pain Relevance 0.04

General Comments

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