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Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
fibroblasts 2
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 47 97.28 Very High Very High Very High
Inflammation 48 89.04 High High
Inflammatory response 8 84.04 Quite High
metalloproteinase 22 77.36 Quite High
antagonist 9 65.28 Quite High
cytokine 13 47.96 Quite Low
Dismenorea 1 36.64 Quite Low
Kinase C 1 20.32 Low Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 28 97.28 Very High Very High Very High
Premature Birth 40 89.36 High High
INFLAMMATION 53 89.04 High High
Pulmonary Disease 3 88.04 High High
Pre-term Labor 13 84.04 Quite High
Infection 35 78.76 Quite High
Colitis 1 77.04 Quite High
Hypertension 4 67.60 Quite High
Osteoarthritis 1 61.92 Quite High
Disease 5 58.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE4 inhibitor cilomilast was also shown to suppress the release and activation of MMP-1 and MMP-9 from lung fibroblasts, which are known to be involved in PF progression [18].
Negative_regulation (suppress) of Positive_regulation (activation) of MMP-1 in fibroblasts associated with fibrosis
1) Confidence 0.11 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.72 Pain Relevance 0.25
We were interested to find that knocking down ET-1 synthesis knocked down MMP-1 upregulation as well.
Negative_regulation (knocked) of Positive_regulation (upregulation) of MMP-1
2) Confidence 0.09 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2913859 Disease Relevance 0.77 Pain Relevance 0.19

General Comments

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