INT314484

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.66 Pain Relevance 0.29

pigmentation (TH) cytosol (TH) mitochondrion (TH) small molecule metabolic process (TH) nucleus (TH) cellular nitrogen compound metabolic process (TH)

TH (Homo sapiens) RLS (Homo sapiens)

Pain Link Frequency Relevance Heat dopamine 88 90.24 Withdrawal 2 83.80 agonist 30 73.92 Biofeedback 2 69.68 tolerance 6 63.04 Carbamazepine 6 49.12 antihistamine 2 14.80 tricyclic antidepressant 2 14.00 sSRI 2 12.36 antagonist 4 5.00

Disease Link Frequency Relevance Heat Restless Legs Syndrome 168 100.00 Syndrome 8 98.28 Sleep Disorders 44 87.44 Thyroid Disease 14 72.60 Disease 12 65.36 Graves' Ophthalmopathy 2 54.72 Anaemia 10 5.00 Hypothyroidism 8 5.00 Pain 4 5.00 Nociception 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

As many patients with normal iron levels have RLS, one cannot assume that elevated TH and low iron levels are the main dysregulations that cause RLS.

TH Positive_regulation (cause) of RLS associated with restless legs syndrome

1) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.92 Pain Relevance 0.07

Moreover, elevated TH is not the only factor that can cause RLS, but it is the inciting condition for the syndrome, not the syndrome on its own.

TH Positive_regulation (cause) of RLS associated with syndrome and restless legs syndrome

2) Confidence 0.01 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882550 Disease Relevance 0.74 Pain Relevance 0.21

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