INT314708

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.75
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Brca2) chromosome organization (Brca2) nucleus (Brca2)
cell cycle (Brca2) DNA binding (Brca2) protein complex (Brca2)
Brca2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 10 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 246 100.00 Very High Very High Very High
Cancer 182 94.96 High High
Bladder Cancer 4 93.88 High High
Skin Cancer 2 93.12 High High
Lymphatic System Cancer 4 92.24 High High
Pancreatic Cancer 2 91.28 High High
Reprotox - General 1 2 90.52 High High
Male Breast Neoplasms 2 87.40 High High
Ovarian Cancer 6 84.52 Quite High
Disease 32 62.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Later, Robson et al200 studied 496 archived tissue blocks (43 cases of BRCA1 mutations, 14 cases of BRCA2 mutations, and 440 control patients); the overall 10-year survival rate was 62% in the BRCA1 mutation group and 86% in the control (P < 0.0001), but there was no difference in the BRCA2 mutation group versus controls.200
Gene_expression (mutations) of BRCA2
1) Confidence 0.41 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.46 Pain Relevance 0
Current studies using CGH and cDNA microarray analysis suggest a distinct signature of chromosome gains and losses and gene expression for the different classes of familial breast cancers (BRCA1, BRCA2, and BRCAX) compared to sporadic breast cancers.194 BRCA1 appears to interact with the p53 protein (leading to induction of the cell-cycle inhibitor p21Cip1/WAF1; Fig. 1)195 directly, with the RNA polymerase holoenzyme, with the transcription factor CREB, with two proteins termed BAP1 and BARD1, with ER?
Gene_expression (expression) of BRCA2 associated with breast cancer
2) Confidence 0.37 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.29 Pain Relevance 0

General Comments

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