INT314746

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Context Info
Confidence 0.32
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Akt1, MDM2) plasma membrane (Akt1, MDM2) enzyme binding (Akt1, MDM2)
cytoplasm (Akt1, MDM2) cytosol (Akt1, MDM2) nucleoplasm (MDM2)
Akt1 (Mus musculus)
MDM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 5 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 5 96.38 Very High Very High Very High
Ovarian Cancer 3 95.82 Very High Very High Very High
Breast Cancer 123 94.00 High High
Cancer 91 74.72 Quite High
Recurrence 9 67.56 Quite High
Disease 16 63.08 Quite High
Death 4 5.76 Low Low
Metastasis 10 5.00 Very Low Very Low Very Low
Carcinoma 7 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was reported that HER2 overexpression in p53 wild-type human ovarian carcinoma cell line induced apoptosis shortly after transfection, while HER2 expression was associated with proliferation in cells with mutated p53.109 It was also reported that HER2/neu induces p53 ubiquitination via Akt-mediated Mdm2 phosphorylation and inactivates p53 in Arf-deficient cells.110 Thus, both ARF and p53 are important genetic determinants in susceptibility to HER2 overexpression in breast cancer.
Akt Positive_regulation (mediated) of Phosphorylation (phosphorylation) of Mdm2 associated with breast cancer, ovarian cancer and apoptosis
1) Confidence 0.32 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.16 Pain Relevance 0

General Comments

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