INT314771

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) signal transduction (Glp1r) extracellular region (Ins1)
plasma membrane (Glp1r) carbohydrate metabolic process (Ins1) cytoplasm (Ins1)
Anatomy Link Frequency
blood 2
beta cell 2
Glp1r (Mus musculus)
Ins1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 8 60.64 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 127 97.60 Very High Very High Very High
Hypoglycemia 32 97.52 Very High Very High Very High
Apoptosis 1 90.04 High High
Hyperglycemia 15 87.88 High High
Autoimmune Disease 1 64.64 Quite High
Impaired Glucose Tolerance 6 60.64 Quite High
Weight Loss 2 50.20 Quite High
Fibrosarcoma 1 47.40 Quite Low
Insulin Resistance 16 5.00 Very Low Very Low Very Low
Obesity 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to its stimulatory effect on insulin secretion, GLP-1 augments insulin biosynthesis and gene transcription, thereby restoring the cellular supplies of insulin for subsequent release.100–103 Of great interest, studies in animals have shown that GLP-1 stimulates islet neogenesis, causes beta cell replication, and inhibits beta cell apoptosis, leading to an increase in beta cell mass.104 However, short-term washout studies with exenatide suggest that exenatide is unlikely to increase beta cell mass in humans.64

Elevated plasma glucagon levels

GLP-1 Positive_regulation (augments) of Gene_expression (biosynthesis) of insulin in beta cell associated with apoptosis
1) Confidence 0.04 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941781 Disease Relevance 0.65 Pain Relevance 0.03
Forced expression of Pdx-1 [38], MafA [39], or GLP-1 [40] in intestinal epithelia by adenovirus-mediated gene transfer induced the expression of insulin and lowered blood glucose levels in streptozotocin-induced diabetic animals.
GLP-1 Positive_regulation (induced) of Gene_expression (expression) of insulin in blood associated with diabetes mellitus
2) Confidence 0.01 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883354 Disease Relevance 0.57 Pain Relevance 0

General Comments

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