INT315064

From wiki-pain
Revision as of 03:41, 21 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RELA) nucleoplasm (RELA) aging (RELA)
nucleus (RELA) DNA binding (RELA) transcription factor binding (RELA)
RELA (Homo sapiens)
PAR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 5 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 215 95.28 Very High Very High Very High
Apoptosis 300 64.00 Quite High
Cancer 115 5.00 Very Low Very Low Very Low
Reprotox - General 1 50 5.00 Very Low Very Low Very Low
Death 30 5.00 Very Low Very Low Very Low
Disease 30 5.00 Very Low Very Low Very Low
Necrosis 20 5.00 Very Low Very Low Very Low
Repression 15 5.00 Very Low Very Low Very Low
Neuroblastoma 15 5.00 Very Low Very Low Very Low
Metastasis 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that inhibition of AKT1 extensively augments Par-4/p65 interactions in cytosol and consequently blocks nuclear translocation of p65.


p65 Binding (interactions) of Par-4
1) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.12 Pain Relevance 0
In scrambled-treated HT29 cells, there was a weak basal signal indicative of a low amount of p65/Par-4 interaction in the cytoplasm (Figure 6; Par4/p65 colocalize panel for scrambled).
p65 Binding (interaction) of Par4
2) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.06 Pain Relevance 0
In scrambled-treated HT29 cells, there was a weak basal signal indicative of a low amount of p65/Par-4 interaction in the cytoplasm (Figure 6; Par4/p65 colocalize panel for scrambled).
p65 Binding (interaction) of Par-4
3) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.06 Pain Relevance 0
Taken together, these results suggest that inhibition of AKT1 extensively augments Par-4/p65 interactions in cytosol and consequently blocks nuclear translocation of p65.


p65 Binding (interactions) of Par-4
4) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.12 Pain Relevance 0
Moreover, co-immunoprecipitation in subcellular fractions followed by Western blot analysis demonstrated that Par-4 associations with p65 and I?
p65 Binding (associations) of Par-4
5) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox