INT315284

Context Info Confidence 0.33 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.85 Pain Relevance 1.56

cytoplasm (PRKG1, Nos1) cytosol (PRKG1, Nos1) plasma membrane (PRKG1, Nos1) mitochondrion (Nos1) aging (Nos1) enzyme binding (Nos1)

Anatomy Link Frequency neuronal 1 PRKG1 (Homo sapiens) Nos1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 2 99.40 Neuropathic pain 9 97.84 Spinal cord 26 93.64 Hyperalgesia 10 92.88 Peripheral nerve injury 3 90.72 excitatory amino acid 1 87.84 qutenza 2 87.64 IPN 8 86.76 spinal dorsal horn 7 85.76 Dorsal horn 2 83.60

Disease Link Frequency Relevance Heat Neuropathic Pain 36 97.84 Hyperalgesia 10 92.88 Nervous System Injury 7 89.84 Inflammatory Pain 8 86.76 Hypersensitivity 1 63.52 Pain 41 59.96 Cv Unclassified Under Development 14 50.00 Injury 21 29.72 INFLAMMATION 4 20.40 Complex Regional Pain Syndromes 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Alternatively, Xu et al. [27] reported that NO, as a retrograde messenger, released glutamate through the presynaptic cGMP-PKG pathway and increased the neuronal NO synthase (nNOS) activity; then NO itself increased NO generation to neuropathic pain along with continued afferent stimuli.

PKG Positive_regulation (increased) of nNOS in neuronal associated with glutamate and neuropathic pain

1) Confidence 0.33 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 0.85 Pain Relevance 1.56

General Comments

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