INT31576

Context Info Confidence 0.69 First Reported 1988 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 0.89 Pain Relevance 0.68

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)

SST (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 16 100.00 abdominal pain 5 83.76 imagery 28 76.44 metalloproteinase 1 68.68 palliative 1 62.88 Bioavailability 1 57.20 agonist 4 50.00 positron emission tomography 7 36.88 Catecholamine 1 6.40 Serotonin 2 5.00

Disease Link Frequency Relevance Heat Cancer 61 99.20 Pancreatic Cancer 3 98.88 Disease 8 89.52 Abdominal Pain 5 83.76 Diarrhoea 6 82.24 Gastrinoma 10 70.28 Gastroesophageal Reflux Disease 2 60.20 Syndrome 13 59.76 Neuroendocrine Cancer 13 50.00 Pituitary Cancer 39 41.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Somatostatin and octreotide: literature review and description of therapeutic activity in pancreatic neoplasia.

Transcription (description) of Somatostatin associated with pancreatic cancer and somatostatin

1) Confidence 0.69 Published 1988 Journal Drug Intell Clin Pharm Section Title Doc Link 2894968 Disease Relevance 0.31 Pain Relevance 0.15

Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.

Transcription (detect) of SST

2) Confidence 0.68 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0

Immunohistochemistry was used to detect adiponectin, beta3-AR, SST, SST2 receptors, tyrosine hydroxylase (TH), and protein gene product 9.5.

Transcription (detect) of SST2

3) Confidence 0.30 Published 2010 Journal Gastroenterology Section Body Doc Link 19786030 Disease Relevance 0 Pain Relevance 0

The GH-lowering effect of SSA is positively correlated with the level of sst2 mRNA expression [27-29].

Transcription (expression) of sst2

4) Confidence 0.15 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC3017030 Disease Relevance 0.09 Pain Relevance 0.15

Octreotide has high affinity for somatostatin receptors, especially subtype 2, resulting in good correlation between scintigraphic findings and the expression of somatostatin receptors on these tumors as determined by immunostaining.

Transcription (expression) of somatostatin associated with cancer and somatostatin

5) Confidence 0.05 Published 2007 Journal Pediatr Radiol Section Body Doc Link PMC2292492 Disease Relevance 0.49 Pain Relevance 0.38

General Comments

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