INT315846

Context Info Confidence 0.00 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.45 Pain Relevance 0

D1Mit315 (Mus musculus) D1Mit315 - T315I (1)

Pain Link Frequency Relevance Heat Central nervous system 7 5.00 Potency 4 5.00 corticosteroid 2 5.00 headache 2 5.00 cytokine 1 5.00 rheumatoid arthritis 1 5.00 imagery 1 5.00 cva 1 5.00

Disease Link Frequency Relevance Heat Myeloid Leukemia 85 80.48 Disease 7 77.60 Cancer 6 74.16 Leukemia 15 50.00 Pleural Effusion 18 5.00 Toxicity 6 5.00 Recurrence 6 5.00 Neutropenia 6 5.00 Pressure And Volume Under Development 5 5.00 Thrombocytopenia 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A possible strategy to suppress the outgrowth of resistant clones is the combination of dasatinib or the other Bcr-Abl TKIs with an inhibitor of T315I.

Negative_regulation (inhibitor) of T315I (T315I)

1) Confidence 0.00 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886328 Disease Relevance 0.45 Pain Relevance 0

General Comments

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