INT316026

Context Info Confidence 0.59 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.04

Anatomy Link Frequency prefrontal 2 AIC (Homo sapiens)

Pain Link Frequency Relevance Heat Somatosensory cortex 5 84.24 medulla 1 13.36 Locus ceruleus 1 8.28 Autonomic response 14 5.00 insula 8 5.00 Central nervous system 4 5.00 primary somatosensory cortex 2 5.00 imagery 2 5.00 Anterior cingulate cortex 1 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 10 56.80 Blindness 8 46.00 Urological Neuroanatomy 3 5.00 Mydriatic 3 5.00 Ganglion Cysts 2 5.00 Unconsciousness 2 5.00 Pain 1 5.00 Epilepsy 1 5.00 Brain Disease 1 5.00 Attention Deficit Hyperactivity Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Preparatory pupil diameter predicts increased activation of AIC and salience/control structures (RCZ rostral cingulate zone, S primary sensory cortex, and task control oculomotor structures IPS intraparietal sulcus, FEF frontal eye field) and decreased activation in the default mode network (aMPFC anterior medial prefrontal cortex, and PCC posterior cingulate cortex).

Positive_regulation (increased) of Positive_regulation (activation) of AIC in prefrontal

1) Confidence 0.59 Published 2010 Journal Brain Struct Funct Section Body Doc Link PMC2886909 Disease Relevance 0.06 Pain Relevance 0.04

General Comments

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