INT316044

Context Info Confidence 0.20 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.37 Pain Relevance 0.32

peptidase activity (Ncstn) Golgi apparatus (Ncstn) endoplasmic reticulum (Ncstn) plasma membrane (Ncstn)

Anatomy Link Frequency brain 1 Ncstn (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 43 95.56 Inflammatory mediators 2 84.72 glial activation 2 73.92 Inflammatory response 14 68.28 Glutamate 1 59.04 Limbic system 1 52.28 chemokine 3 24.88 Hippocampus 6 21.72 cytokine 9 11.44 cINOD 36 5.00

Disease Link Frequency Relevance Heat Disease 81 99.20 Head Trauma 1 97.36 Brain Injury 3 96.84 INFLAMMATION 60 95.56 Gliosis 3 85.68 Brain Disease 4 85.36 Alzheimer's Dementia 9 46.76 Amyloid Plaque 11 37.60 Targeted Disruption 18 34.84 Hypoxia 5 34.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Levels of PS1 and nicastrin increase significantly in activated astrocytes and microglia following brain damage by head injury, brain stabbing and inflammatory insult (Nadler et al., 2008).

Positive_regulation (increase) of nicastrin in brain associated with inflammation and brain injury

1) Confidence 0.20 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.37 Pain Relevance 0.32

General Comments

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