INT316044

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.37
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ncstn) Golgi apparatus (Ncstn) endoplasmic reticulum (Ncstn)
plasma membrane (Ncstn)
Anatomy Link Frequency
brain 1
Ncstn (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 43 95.56 Very High Very High Very High
Inflammatory mediators 2 84.72 Quite High
glial activation 2 73.92 Quite High
Inflammatory response 14 68.28 Quite High
Glutamate 1 59.04 Quite High
Limbic system 1 52.28 Quite High
chemokine 3 24.88 Low Low
Hippocampus 6 21.72 Low Low
cytokine 9 11.44 Low Low
cINOD 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 81 99.20 Very High Very High Very High
Head Trauma 1 97.36 Very High Very High Very High
Brain Injury 3 96.84 Very High Very High Very High
INFLAMMATION 60 95.56 Very High Very High Very High
Gliosis 3 85.68 High High
Brain Disease 4 85.36 High High
Alzheimer's Dementia 9 46.76 Quite Low
Amyloid Plaque 11 37.60 Quite Low
Targeted Disruption 18 34.84 Quite Low
Hypoxia 5 34.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of PS1 and nicastrin increase significantly in activated astrocytes and microglia following brain damage by head injury, brain stabbing and inflammatory insult (Nadler et al., 2008).
Positive_regulation (increase) of nicastrin in brain associated with inflammation and brain injury
1) Confidence 0.20 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.37 Pain Relevance 0.32

General Comments

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