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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Erbb4, Nrg1) plasma membrane (Erbb4, Nrg1) mitochondrion (Erbb4)
cell morphogenesis (Nrg1) cell proliferation (Nrg1) signal transduction (Erbb4)
Anatomy Link Frequency
Notch 1
radial 1
Erbb4 (Mus musculus)
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 62.32 Quite High
interneuron 2 16.52 Low Low
medulla 1 15.20 Low Low
Hippocampus 7 12.36 Low Low
Pyramidal cell 1 11.60 Low Low
Inflammation 43 5.00 Very Low Very Low Very Low
cINOD 36 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 11 79.24 Quite High
Targeted Disruption 18 72.88 Quite High
Nervous System Malformation 1 62.80 Quite High
Disease 81 55.92 Quite High
Frontotemporal Dementia 8 54.96 Quite High
Hypoxia 5 31.88 Quite Low
Brain Injury 3 31.40 Quite Low
Apoptosis 2 7.52 Low Low
Death 4 6.32 Low Low
INFLAMMATION 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further elucidate the mechanism of radial glial radialization induced by NRG1, MAM slices were cultured in medium containing recombinant NRG1 (1 nM) combined with HER-3 Ab-5 or HER-4 Ab-3, two antibodies blocking the binding of NRG1 to erbB3 and erbB4 respectively (Figure S1).
erbB4 Binding (binding) of NRG1 in radial
1) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Similarly to Notch processing, upon neuregulin binding and activation of ErbB4, ?
ErbB4 Binding (binding) of neuregulin in Notch
2) Confidence 0.02 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.38 Pain Relevance 0.03

General Comments

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